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EURADOS Report 2021-04 published: "EURADOS Intercomparison on Compartmental Model for 18F-FDG Developed by Hays and Segall"

10 August '21
EURADOS Reports

EURADOS Report 2021-04 is published: "EURADOS Intercomparison on Compartmental Model for 18F-FDG Developed by Hays and Segall"

Wei Bo Li, David Broggio, Augusto Giussani, Tomáš Vrba, Kerstin Hürkamp, Alexandra Kamp, Dietmar Noßke, Lara Struelens, Peter Covens

Abstract: This report was originated from the analysis of the results of a joint EURADOS-EANM project about
the assessment of the external radiation dose rate to comforters and caregivers exposed to patients
undergoing nuclear medical diagnostics and therapy. The compartmental model for 18F-FDG
developed by Hays and Segall in 1999 was applied by EURADOS members for predicting the time
activity curves (TAC) in the source organs and tissues, and the urinary excretion. Inconsistencies have
been found between the TAC and the time integrated activity coefficients (TIAC) calculated by
EURADOS and those published by Hays and Segall and the Committee on Medical Internal Radiation
Dose (MIRD). A quality assurance in form of an intercomparison on the implemented Hays and Segall
compartmental model for 18F-FDG was carried out between four institutions of EURADOS voting
members to validate the model predictions. The differences in calculated TIAC between EURADOS
and MIRD results reach up to a factor of 3.2 by using arithmetic mean model parameters and 3.8 by
using geometric mean parameters. The inconsistencies are under investigation in contact with MIRD
Committee. A suggestion of updating the compartmental model for 18F-FDG with new available data
is made.

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